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Robert R Bies Selected Research

Chlorzoxazone

12/2011Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.
3/2006Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.
12/2003Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.

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Robert R Bies Research Topics

Disease

22Schizophrenia (Dementia Praecox)
10/2019 - 11/2002
11Neoplasms (Cancer)
01/2022 - 03/2005
5Alzheimer Disease (Alzheimer's Disease)
02/2016 - 06/2005
4Body Weight (Weight, Body)
02/2016 - 01/2010
4Hypothermia
10/2013 - 03/2006
3Breast Neoplasms (Breast Cancer)
10/2021 - 01/2011
3Prostatic Neoplasms (Prostate Cancer)
06/2018 - 09/2006
2Neutropenia
01/2022 - 01/2013
2Type 2 Diabetes Mellitus (MODY)
01/2019 - 03/2014
2Dyskinesias (Dyskinesia)
05/2014 - 03/2014
2Drug-Related Side Effects and Adverse Reactions
10/2013 - 01/2012
2Psychotic Disorders (Schizoaffective Disorder)
04/2012 - 01/2012
2Heart Arrest (Cardiac Arrest)
12/2011 - 03/2006
2Dementia (Dementias)
12/2010 - 06/2005
2Mental Disorders (Mental Disorder)
12/2009 - 12/2008
1Leukopenia
10/2021
1Lymphoma (Lymphomas)
01/2020
1Hallucinations (Hallucination)
10/2019
1Diabetic Nephropathies (Diabetic Nephropathy)
01/2019
1Disease Progression
10/2016
1Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive)
10/2015
1Treatment-Resistant Schizophrenia
08/2014
1Psychomotor Agitation (Akathisia)
05/2014
1Tardive Dyskinesia
03/2014
1Cognitive Dysfunction
10/2013
1Traumatic Brain Injuries (Traumatic Brain Injury)
10/2013
1Hyperprolactinemia
08/2013
1Bipolar Disorder (Manic Depressive Psychosis)
03/2013
1Kidney Neoplasms (Kidney Cancer)
04/2012
1Anxiety Disorders (Anxiety Disorder)
12/2010
1Neuralgia (Stump Neuralgia)
08/2010
1Hyperalgesia
08/2010

Drug/Important Bio-Agent (IBA)

12Risperidone (Risperdal Consta)FDA LinkGeneric
10/2019 - 06/2005
12Antipsychotic Agents (Antipsychotics)IBA
07/2019 - 02/2008
10Olanzapine (Zyprexa)FDA Link
10/2019 - 02/2008
10Pharmaceutical PreparationsIBA
10/2016 - 11/2002
5Dopamine D2 Receptors (Dopamine D2 Receptor)IBA
03/2014 - 04/2012
3Irinotecan (Camptosar)FDA LinkGeneric
01/2022 - 01/2020
3Epirubicin (Ellence)FDA LinkGeneric
10/2021 - 01/2011
3Dopamine (Intropin)FDA LinkGeneric
05/2015 - 10/2013
3Clozapine (Clozaril)FDA LinkGeneric
08/2014 - 06/2009
3Docetaxel (Taxotere)FDA Link
01/2013 - 09/2006
3Cytochrome P-450 CYP3AIBA
12/2011 - 06/2007
3Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
12/2011 - 12/2003
3ChlorzoxazoneFDA LinkGeneric
12/2011 - 12/2003
2Glucuronosyltransferase (UDP Glucuronosyltransferase)IBA
10/2021 - 04/2016
2UridineIBA
10/2021 - 04/2016
2Fluorouracil (Carac)FDA LinkGeneric
01/2020 - 04/2016
2Biomarkers (Surrogate Marker)IBA
01/2019 - 10/2015
2Perphenazine (Trilafon)FDA LinkGeneric
05/2014 - 01/2010
2ziprasidone (Geodon)FDA Link
03/2014 - 11/2011
2CytochromesIBA
12/2011 - 03/2006
2Midazolam (Versed)FDA LinkGeneric
12/2011 - 05/2010
2BenzodiazepinesIBA
05/2010 - 10/2009
2AtrasentanIBA
09/2006 - 09/2005
2Endothelins (Endothelin)IBA
09/2006 - 09/2005
2Cytochrome P-450 CYP2E1 (CYP2E1)IBA
03/2006 - 12/2003
1DNA (Deoxyribonucleic Acid)IBA
01/2022
1BilirubinIBA
01/2022
1Antineoplastic Agents (Antineoplastics)IBA
01/2020
1Bevacizumab (Avastin)FDA Link
01/2020
1Leucovorin (Folinic Acid)FDA Link
01/2020
1Paliperidone PalmitateFDA Link
10/2019
1Dihydrotestosterone (Androstanolone)IBA
06/2018
1AndrogensIBA
06/2018
1Cyclophosphamide (Cytoxan)FDA LinkGeneric
04/2016
1CitalopramFDA LinkGeneric
02/2016
1desmethylcitalopramIBA
02/2016
1CreatinineIBA
07/2015
1Sitagliptin Phosphate (Januvia)FDA Link
03/2014
1Dipeptidyl-Peptidase IV InhibitorsIBA
03/2014
1Phenytoin (Dilantin)FDA LinkGeneric
10/2013
1ProlactinIBA
08/2013
1Lamotrigine (Lamictal)FDA LinkGeneric
03/2013
1Memantine (Namenda)FDA Link
03/2013
1Sertraline (Zoloft)FDA LinkGeneric
02/2013
1Growth InhibitorsIBA
07/2012
117- (dimethylaminoethylamino)- 17- demethoxygeldanamycinIBA
07/2012
1Sorafenib (BAY 43-9006)FDA Link
04/2012
1norclozapineIBA
01/2012
1Dextromethorphan (Racemethorphan)FDA LinkGeneric
12/2011
1EnzymesIBA
12/2011
1Protein Isoforms (Isoforms)IBA
12/2011
1cytochrome P-450 CYP2C subfamilyIBA
12/2011
1salicylhydroxamic acid (SHAM)IBA
12/2011
1Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA
12/2010
1EscitalopramFDA Link
12/2010
1Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
12/2010
1Pregabalin (Lyrica)FDA Link
08/2010
1Sildenafil Citrate (Viagra)FDA Link
08/2010
1MagnesiumIBA
05/2010
1Cytochrome P-450 CYP2C19IBA
01/2010

Therapy/Procedure

8Therapeutics
01/2020 - 09/2005
6Drug Therapy (Chemotherapy)
01/2022 - 11/2002
3Drug Tapering
07/2019 - 09/2013
3Induced Hypothermia
10/2013 - 03/2006
2Cell Transplantation
10/2015 - 03/2014
1Castration
06/2018
1Secondary Prevention
11/2014
1Rewarming
10/2013